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Username: grumpybob

Name: Robert Saunders

Joined: 13 Sep 2011

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Links 1 through 10 of 37 by Robert Saunders tagged BSRA

"Here we investigated the 8 regulation of telomere length and its control of senescence heterogeneity. Because the length 9 of the shortest telomeres can potentially regulate cell fate, we focus on their dynamics in 10 Saccharomyces cerevisiae. We developed a stochastic model of telomere dynamics built on 11 the protein-counting model, where an increasing number of protein-bound telomeric repeats 12 shift telomeres into a non-extendable state by telomerase."

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Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in fifteen study centers of eleven European countries as part of the Genetics of Healthy Ageing (GEHA) project.

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Ubiquitously reduced signaling via Methuselah (MTH), a G-protein coupled receptor (GPCR) required for neurosecretion, has previously been reported to extend life and enhance stress resistance in flies. Whether these effects are due to reduced MTH signaling only in specific tissue(s) and through with signaling effects reduced MTH might produce these phenotypes remains unknown. We determined that reduced expression of mth targeted only to the insulin-producing cells (IPCs) of the fly brain was sufficient to extend life and enhance oxidative stress resistance.

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This is an unique cohort of Dutch families with extended survival across generations, decreased morbidity and beneficial metabolic profiles in middle-age. By comparing mRNA levels of nonagenarians and middle-aged controls, the mTOR signalling gene set was found to associate with old age.

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News item about a trial of farnesyltransferase inhibitors as HGP therapy

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A 25 year NIA study on caloric restriction in rhesus monkeys reveals it improves health, but not lifespan.

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